B
Next Generation Transformation
Since June 2024, BPP GmbH is accepting (pre-)orders for our newest proprietary gene delivery technology at the introductory price.
BPP Bioportide™ are peptide-based transformation/transfection agents that actively transport nucleic acids, i.e. DNA and RNA, across the plasma membrane of a wide range of host cells and cell types. This achieved using specialized cell-penetrating peptide moieties that are able to sponantously insert into biomembranes.
We contantly test, improve and expand our repertoire of BPP Bioportide™ variants and plan to offer various transformation/transfection kits in the future.
The start makes BPP Bioportide™ BP17, which has shown excellent results in gram-negative bacteria, in particular E. coli.
For more information, please follow the link below.
Figure | Mock-up of our new BPP Bioportide™ Kit for bacterial transformation.
From our and our scientific partners' studies, it becomes clear that BPP Bioportide™ are capable of transforming and transfecting a wide range of model organisms from various domains of life, showing particularly interesting results not only in bacteria (e.g. Steptomyces) but also lower and higher eukaryotes (e.g. yeast and plants). For this reason, we have put together a test kit comprising 10 of our most potent BPP Bioportide™ variants for you to transform your model organism of choice. Find which BPP Bioportide™ is working best for you, we are looking forward to supporting you in your research. Learning from one another, we hope to accelerate research and find tailored solutions in gene delivery.
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Suspendisse tincidunt sagittis eros. Quisque quis euismod lorem. Etiam sodales ac felis id interdum.
Figure | Mock-up of our new Bioportide Kit for bacterial transformation.
Figure | Representation and overview of BPP Technologies.
"Nature is nothing that needs to be overcome."
Functional bioactive peptides and proteins have an enormous but underutilised economical potential to improve the ecological balance in several major industry sectors producing or processing biological material, for instance, the agriculture, food, pharma or cosmetic sector.
For example, antimicrobial peptides can protect sensitive crop and/or temporarily prepare them naturally for climate change-related environmental impacts, such as droughts and pests, without the disadvantages of risking formation of resistence, hazardous residues and drift into adjacent soils or groundwater. Furthermore, in the production of vegan meat, the availability of protein-based growth factors plays a crucial role, and as flavour modulators, peptides can significantly reduce added sugars.
The problem? The availability!
The Better Peptides Platform, our award winning, proprietary core technology, allows us to manufacture virtually any complex linear or circular peptide of 15-150 amino acid length from simple harmless biological ingredients at industry relevant scales. From this unique capability alone, a multitude of opportunity arises that were never before thought to be possible. In only a few years since founding of the BPP GmbH, the platform has become an ecosystem. Major strifes have been made to further improve upon the technology and develop exciting new applications around it. Only recently, Bioportides were introduced with resounding feedback from laboratories that have tested it. Bioportides are a peptide-based transformation/transfection agents for nucleotide delivery and we are actively researching on exciting new ways to use our unique biotechnological peptide synthesis approach to solve pressing challenges in peptide candidate screening.
"Bioeconomics provides a strategic advantage, because it provides a general, desirable, and worthwhile added benefit compared to conventional methods."
The basis of our Better Peptides Platform is a well engineered, multi-functional, and patented designer fusion protein for expression, protection, isolation, purification, and on-demand release of tailor-made linear and circular peptides. In other words, the BPP fusion protein comes with (almost) all molecular tools needed to clean itself.
Briefly, the BPP fusion protein consists of three noteworthy domains:
First, the Carrier & Binding (CB) Domain has a strong tendency to agglomerate in inclusion bodies when expressed in bacterial cultures (see advantages below). In addition, it exhibits a natural affinity to readily available and inexpensive biological purification matrixes allowing it to be purified in high yields (> 95%) using simple, reliable, and scalable chromatography processes. No hazardous solvents required!
Second, our Smart Release (SR) Domain (patent pending) exhibits an optimized pH-sensitive proteolytic activity that represents a well controlled release trigger of the final product. Most importantly, it releases the target linear or cyclic peptide or protein with authentic termini, i.e. there are no process related amino acid residues or elimination reactions.
Lastly, there is the Payload (P). The payload is your custom linear or cyclic peptides of 20 - 250 amino acid length. The possibilities are virtually limitless.
You already have a linear or cyclic peptide candidate that you would like to move into a flexible and scalable production pipeline? The Better Peptides Platform is probably the answer. Please contact us and we work together on a solution for your production needs.
In addition, we have a few promising peptide and protein candidates of our own, ready to be taken into culture and to be produced on demand.
Figure | Bioeconomy Innovation Award 2023.
Badische Peptide und Proteine GmbH has won the Bioeconomy Innovation Award 2023 and was able to convince the attending entrepeneurs and bioscientists from numerous fields of research of its strategical advantages for a future-oriented biobased peptide-industry build from renewable biological resources.
Are you looking for a cost-effective and clean solution for the production of peptides and proteins for your scientific projects, your research or your product production? Then you've come to the right place.
The BPP GmbH is a young dynamic biotech start-up company located in Mannheim, Germany. We are specializing in the biotechnological production and analysis of peptides and proteins. Take advantage of our proprietary Better Peptides Producution Platform to scale the production of your custom-made linear or circular peptides and protein candidates for use in agriculture, pharma, food, or cosmetics. We are looking forward to advise and work with you personally on economical and ecological solutions to scale your production.
Thanks to a range of propietary platform technologies for the production of linear and cyclic peptides and proteins, BPP is able to offer you customised solutions for your projects. There are virtually no limits to the possibilities. BPP is happy to accompany you from the first test expression to production on a gram scale and beyond.
As the chemical synthesis of peptides and proteins is labour- and resource-intensive, BPP relies on the use of green biotechnology. Its peptides and proteins are produced recombinantly and then released and purified using the BPP process. Our process makes it possible to dispense with the use of environmentally harmful organic solvents.
BPP conducts its own research and is constantly developing new and improved processes in order to be able to respond flexibly and precisely to the requirements of its customers.Equipped with modern laboratory technology, BPP offers a wide range of methods for protein analysis and can thus not only respond to our customers' wishes, but also ensure the quality of the products throughout the entire process. Our methods include photometry, various options for enzyme assays, gel analysis, chromatography (HPLC/FPLC) and MALDI-TOF mass spectrometry.
Badische Peptide und Proteine GmbH is funded as part of the Baden-Württemberg state strategy for a sustainable bioeconomy.
'%3e%3cg id='Final-Copy-2_2_' transform='translate(1275.000000, 200.000000)'%3e%3cpath class='st0' d='M7.4,12.8h6.8l3.1-11.6H7.4C4.2,1.2,1.6,3.8,1.6,7S4.2,12.8,7.4,12.8z'/%3e%3c/g%3e%3c/g%3e%3c/g%3e%3cg id='final---dec.11-2020'%3e%3cg id='_x30_208-our-toggle' transform='translate(-1275.000000, -200.000000)'%3e%3cg id='Final-Copy-2' transform='translate(1275.000000, 200.000000)'%3e%3cpath class='st1' d='M22.6,0H7.4c-3.9,0-7,3.1-7,7s3.1,7,7,7h15.2c3.9,0,7-3.1,7-7S26.4,0,22.6,0z M1.6,7c0-3.2,2.6-5.8,5.8-5.8 h9.9l-3.1,11.6H7.4C4.2,12.8,1.6,10.2,1.6,7z'/%3e%3cpath id='x' class='st2' d='M24.6,4c0.2,0.2,0.2,0.6,0,0.8l0,0L22.5,7l2.2,2.2c0.2,0.2,0.2,0.6,0,0.8c-0.2,0.2-0.6,0.2-0.8,0 l0,0l-2.2-2.2L19.5,10c-0.2,0.2-0.6,0.2-0.8,0c-0.2-0.2-0.2-0.6,0-0.8l0,0L20.8,7l-2.2-2.2c-0.2-0.2-0.2-0.6,0-0.8 c0.2-0.2,0.6-0.2,0.8,0l0,0l2.2,2.2L23.8,4C24,3.8,24.4,3.8,24.6,4z'/%3e%3cpath id='y' class='st3' d='M12.7,4.1c0.2,0.2,0.3,0.6,0.1,0.8l0,0L8.6,9.8C8.5,9.9,8.4,10,8.3,10c-0.2,0.1-0.5,0.1-0.7-0.1l0,0 L5.4,7.7c-0.2-0.2-0.2-0.6,0-0.8c0.2-0.2,0.6-0.2,0.8,0l0,0L8,8.6l3.8-4.5C12,3.9,12.4,3.9,12.7,4.1z'/%3e%3c/g%3e%3c/g%3e%3c/g%3e%3c/g%3e%3c/svg%3e)
