Better Peptides Platform

Scaling Peptide Production Sustainably

"The problem? The availability!"

Tackling the Urgent need for a Future-Proof Peptide Production platform

Functional bioactive peptides and proteins have an enormous yet underutilised economic potential to improve the ecological balance in several major industry sectors producing or processing biological material, be it agriculture, food, pharma, or cosmetics.

The problem? The availability!

The Better Peptide Platform aims to change that substancially and is coming head strong after conventional solid-phase peptide synthesis as the gold standard in commercial peptide production and its desastrous ecological footprint, producing tons of hazardous organic solvent waste per year, its economically unviable cost of production, and its limitations to produce truly tailor-made complex peptides at industry-relevant scales.

Features

Give your Peptides A Strategical Advantage

Linear And Circular Peptides

Modular design of the carrier fusion protein allows for the production of both, linear and circular peptides. Only few conditions apply for circulation of peptides.

Functional Molecular Design

Forward-looking carrier fusion design combines all molecular tools to simplify downstream processing.

Complex Peptides

Ideal for peptides of 20-150 amino acid length, the Better Peptides Platform closes a critical gap between solid-phase peptide synthesis and recombinant protein expression.

Native Sequences

Tailor-made Better Peptides are released from the carrier fusion protein without process-related modifications, scars or residual amino acids for native termini.  

High Yield | High Purity

Utilizing host cell biology, Better Peptides are naturally protected from modifications, available in high yields, and of high purity with minimal downstream processing.

Unrivaled Scalability

From milligrams of peptide candidates to multi-ton commerical stage peptide-based products, the range of production scale is virtually limitless.

No Hazardous Substances

The Better Peptides Platform requires no specialized chemicals (e.g. protected amino acids) and hazardous organic solvents (e.g. acetonitrile, DMF etc.).

Cost Effective

Smart molecular engineering, readily available common renewable biological resources, no need for specialized equipment or chemicals, and economy of scale contribute to keep production costs low and offer new commericially viable opportunities.

AWARDS

AWARD Winning

"Bioeconomics  provides a general, desirable, and worthwhile added benefit compared to conventional methods."

The Value of Bioeconomics

Badische Peptide und Proteine GmbH has won the Bioeconomy Innovation Award 2023 and was able to convince the attending entrepeneurs and bioscientists from a broad range of research fields of its strategical advantages for a future-oriented biobased peptide-industry build from renewable biological resources.

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Figure | Bioeconomy Innovation Award 2023.

Sectors

Better PEptides in Agriculture

The problems associated with the widespread use of conventional chemical-synthetic crop protection are significant. The problems reach from resistence formation, hazardous residues lingering and drifting into adjacent soils and groundwater to adverse effects with far-reaching implications for biodiversity (e.g. loss of polinators) and human health (e.g. allergies and cancer).

Biologically and sustainably produced bioactive peptides and proteins have a great potential of naturally protecting sensitive crop and harvest plants from climate change related enviromental changes, such as droughts, or temporarily prepare them for pests using the plants own defence mechanisms.
In many instances, peptide-based solutions come a long way in avoiding and replacing conventional chemical herbicides, fungicides and pesticides. In cases where they can't be avoided entirely, their use can at least be reduced to a minimum.

Now, for the first time, the unrivaled scalability of our propietary Better Peptides Platform enables the widespread use of antimicrobial peptides on a commercial scale and provide a cost effective and ecologically friendly alternative to conventional crop protection.

Additionally, the Badische Peptide und Proteine GmbH in collaboration with University of Saarbrücken and developed a novel peptide-based reagent for transient transfection of a diverse set of host organisms, including plants. We call the technology BPP BioportidesTM and it is as easy as watering your plant.

Does this peak your interest? Then please contact us, we are still looking for scientific partners helping us further investigate the limits of this technology under routine conditions.

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Sectors

Better Peptides in Food Industry

Peptides and proteins are a natural and integral part of our nutrition. They provide us with the necessary essential amino acids and nitrogen compounds to maintain a healthy life. However, beside the obvious nutritious value of a good and solid protein basis, affordable ecologically sourced functional peptides and proteins can provide a significant added benefit in food production.

The best example is vegan meat, also often referred to as "cultured meat" or "lab-grown meat". For it to have the intended beneficial effect on the enviroment, reduce mass animal farming and become commercially successful, availability of recombinantly expressed animal growth factors play a crucial role to meet the demand of vegan meat production. For this to work, the importance of cost effective and scalable peptide and protein production cannot be stressed enough. Growth factors would need to be produced in large quantifies in an animal free setting and according to the highest standards of food production.

Another interesting case study to highlight the benefits of the Better Peptides Platform are taste modulators and flavors. Peptides can either be used directly as spices, natural sweetener or flavors, or indirectly by modulating taste by inhibiting receptors of undesired tastes. Such peptides have the potential to significantly reduce the amount of added sugars, artifical sweetener and flavours used in the food industry with various beneficial effects on consumer's health.

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Sectors

Better Peptides in Pharma

As proteins and peptides fullfil numerous vital cellular functions, they also play a crucial role in human and veterinary health care.

Only recently, during the SARS-COV2 pandemic, we learned how important the ability is to produce biological material fast and on scale, be it for research or production purposes. Pharmaceutical research is a fast pace enviroment, in which a multitude of compounds need to be produced, tested and rejected or approved to find the ideal candidate for clinical trials. The turnover and development times are crucial for commerical success.

The Better Peptides Platform is optimally suited for the needs of research and development and allows for a prompt production of custom linear and circular peptide candidates in various scale. Once a suitable peptide drug candidate was found, the production can quickly be ramped up to meet commerical demands using the same established technology used to produce the research candidates. This saves important time. More importantly, the platform is reliable and reproducibly independent of the cargo peptide produced, because vital elements of the process are kept constant and the method do not require tidious finetuning.

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Sectors

Better Peptides in Cosmetics

Peptides and proteins are part of the first line of defence the body uses to protect itself from the daily onslaught of enviromental stress factors and maintain the vital fine-tuned homeostasis to maintain a working and healthy skin barrier.

Usually secreted with the sweat, peptides and proteins are part of the protective layer forming and coating the epithelial cells fulfilling numerous vital functions. By their composition, they regulate moisture content or the neutral pH of the skin. Some, like Dermacidin, have cell permeability properties that allow the transport of nutrition through the various layers of the skin.

Cosmetic products enriched with affordable endogenous bioactive peptides and proteins could support maintaining or reestablishing the homeostasis of our largest organ, when it is once again stessed or damaged.

Skin care is health care. Thematically related to Pharmaceutical research, also cosmetics can benefit greatly from the availability of bioactive peptide incredients and the benefits of the Better Peptides Platform for producing peptides and proteins.

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Interested?

Order Your Better PEptides Today! 

You already have a linear or cyclic peptide candidate that you would like to move into a flexible and scalable production pipeline?

Then, the Better Peptides Platform is probably the right choice for you. Please contact us and we work together on a solution for your production needs.

Christoph Kutzner

CEO and Founder

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